Dr. Adriana San Miguel Delgadillo

Dr Adriana San Miguel Delgadillo

Chemical and Biomolecular Engineering

Phone: 919-515-2934
Instructor Website

CHE 596 612 Systems Biology

3 Credit Hours

This course is an introduction to Systems Biology. The purpose is for students to analyze biological processes from a perspective where multiple entities are dynamically working together. We will learn about the fundamentals of systems biology, about experimental and analytical tools used in systems biology, and how engineering, mathematics, and computation have been crucial in the development of this field.


Introductory Biology: Cellular and Molecular Biology (NC State BIO 183) or its equivalent

Basic knowledge of biology (DNA, RNA, proteins, cells, etc.) is assumed.

Course Structure

In this course, we will have alternating lectures, discussion sessions, and workshop-style classes. Discussions will be carried out in small groups, and will then be opened to the entire class. Discussion topics will include: papers, case studies, or problem solving. In workshop-style classes, we will go over techniques (mainly data analysis or algorithms), and work examples in class, for these, you will need your laptop with the required software.

Course Topics

  • An introduction to systems biology: Studying organisms as a collection of thousands of moving parts: transcriptomics, proteomics, etc.
  • Networks: Deciphering how a multitude of molecular and biological entities function together to determine function
  • Phenotyping: Quantitative representation of organismal characteristics and functions
  • High-throughput, high-content systems: Engineering systems for high-content image-based acquisition and analysis
  • Engineering, math, and computation in systems biology: Image processing, modeling, algorithms for data management and mining
  • Systems biology applications in disease and pharmacology

Course Requirements

Quizzes – most in-class 10%
Homework – one or two per topic 30%
Group discussion 30%
Final project 30%

There will be no exams in this class.


Handbook of Systems Biology: Concepts and Insights. Walhout, Vidal, & Dekker. Academic Press, 2012 (available online for NCSU students)

Computer and Software Requirements

Please review minimum computer specifications recommended by NC State University and Engineering Online.

Updated 04/22/2021