Dr Adriana San Miguel Delgadillo
Chemical and Biomolecular Engineering
CHE 596 612 Systems Biology
3 Credit Hours
This course is an introduction to Systems Biology. The purpose is for students to analyze biological processes from a perspective where multiple entities are dynamically working together. We will learn about the fundamentals of systems biology, about experimental and analytical tools used in systems biology, and how engineering, mathematics, and computation have been crucial in the development of this field.
Introductory Biology: Cellular and Molecular Biology (NC State BIO 183) or its equivalent
Basic knowledge of biology (DNA, RNA, proteins, cells, etc.) is assumed.
In this course, we will have alternating lectures, discussion sessions, and workshop-style classes. Discussions will be carried out in small groups, and will then be opened to the entire class. Discussion topics will include: papers, case studies, or problem solving. In workshop-style classes, we will go over techniques (mainly data analysis or algorithms), and work examples in class, for these, you will need your laptop with the required software.
- An introduction to systems biology: Studying organisms as a collection of thousands of moving parts: transcriptomics, proteomics, etc.
- Networks: Deciphering how a multitude of molecular and biological entities function together to determine function
- Phenotyping: Quantitative representation of organismal characteristics and functions
- High-throughput, high-content systems: Engineering systems for high-content image-based acquisition and analysis
- Engineering, math, and computation in systems biology: Image processing, modeling, algorithms for data management and mining
- Systems biology applications in disease and pharmacology
|Quizzes – most in-class||10%|
|Homework – one or two per topic||30%|
There will be no exams in this class.
Handbook of Systems Biology: Concepts and Insights. Walhout, Vidal, & Dekker. Academic Press, 2012 (available online for NCSU students)
Computer and Software Requirements
Please review minimum computer specifications recommended by NC State University and Engineering Online.