Instructor

Dr. Kirill Efimenko

Dr. Kirill Efimenko

Chemical and Biomolecular Engineering

Phone: 919-513-0548
Email: efimenko@ncsu.edu
Instructor Website

CHE 596 625 Drug Delivery – Theory and Modern Practices

3 Credit Hours

The course discusses conventional and advanced drug delivery methods and systems.

Prerequisite

Organic chemistry, calculus.

Course Objectives

This course will enable:

  • Understand and describe the general concepts of conventional drug delivery: affinity, efficacy, and pharmakinetics.
  • Understand the governing principles of controlled drug delivery and contemporary approaches to administer therapeutical agents.
  • Understand the benefits of nanoscale materials in replacing currently used drug delivery approaches.
  • Assess, design and practice common methods associated with the preparation and characterization of nanotherapeutics.

Course Topics

  1. Pharmacology: The Chemical Control of Physiology.
  2. Drug affinity and Efficacy.
  3. Pharmacokinetics I: Permeation and Metabolism.
  4. Pharmacokinetics II: Distribution and Multiple Dosing.
  5. Conventional Drug Formulations.
  6. Challenges of Conventional Drug Delivery Formulations.
  7. Controlled Drug Delivery.
  8. Novel Approaches to Drug Delivery.
  9. Nanoscale Systems: Synthesis.
  10. Nanoparticle Stabilization and Property Control.
  11. Vesicle-Based Drug Carriers: Liposomes, Polymersomes, and
    Niosomes.
  12. Polymeric Micelles.
  13. Hydrogels. Biomedical Application.
  14. Novel Nanoscale Detection Systems.
  15. Cancer Nanotherapeutics.
  16. Novel Approaches to mAb Formulations and Delivery.
  17. Case Studies on Disease Treatment Using Nanotherapeutics.

Course Requirements

In-class quizzes. There will be short in-class quizzes during the class period. These will usually cover material assigned as homework or extra reading. The purpose is to encourage you to stay current on reading and homework assignments. The quizzes contribute a significant portion to the final grade.

Mid-term exam. There is one mid-term exam in the semester.

Final presentation. At the end of the course, students will be required to prepare a final oral presentation and present their results to the instructor and the class on one of the selected course topics selected by the instructor.

Final Exam. The comprehensive exam covering all subjects of the course.

Research paper
At the end of the course student will be required to write an independent review research paper related to one of the focus topics of the course. The subject of the review paper will be chosen by the student from the database of the research areas relevant to modern drug delivery provided by the instructor at the beginning of the course. The final document is due one week before the last day of regular classes. It should contain at least seven written pages, font 12, single paragraph. The reference pages will not be counted toward total number of pages of the final document.

Textbook

Instructors course pack (free of charge)

Computer and Software Requirements

Please review minimum computer specifications recommended by NC State University and Engineering Online.

Updated 10/21/2022